Aphrodyne information, interactions and side effects, Yohimbine is a 3a-15a-20(beta)-17a- hydroxy Yohimbine-16a-carboxylic acid methyl ester. The alkaloid is found in Rubaceae and related trees and is also found in Rauwolfia Serpentina (L) Benth.

Yohimbine is an indolalkylamine alkaloid with chemical similarity to reserpine. It is a crystalline powder, odorless. Each compressed caplet contains 5.4 mg (1/12 gr.) of Yohimbine Hydrochloride.


APHRODYNE (yohimbine) ® is indicated as a sympatholytic and mydriatic. Impotence has been successfully treated with yohimbine in male patients with vascular or diabetic origins and psychogenic origins (18 mg/day).


Experimental dosage reported in treatment of erectile impotence: 1,3,4 1 caplet (5.4mg) 3 times a day, to adult males taken orally. Occasional side effects reported with this dosage are nausea, dizziness or nervousness. In the event of side effects dosage is to be reduced to 1/2 caplet 3 times a day, followed by gradual increases to 1 caplet 3 times a day. Reported therapy not more than 10 weeks.


APHRODYNE (yohimbine) ® scored caplets are aqua, debossed with APHRO DYNE. They are available in bottles of 100 NDC 0076-0401-03) and 1000 (NDC 0076-0401-04).

Star Pharmaceuticals, Inc.


Yohimbine readily penetrates the CNS and produces a complex pattern of responses in lower doses than required to produce peripheral (alpha)-adrenergic blockage. These include anti-diuresis, a general picture of central excitation including elevated blood pressure and heart rate, increased motor activity, irritability and tremor. Sweating, nausea and vomiting are common after parenteral administration of the drug. Also dizziness, headache, and skin flushing have been reported.


Generally, this drug is not proposed for use in females and certainly must not be used during pregnancy. Neither is this drug proposed for use in pediatric, geriatric or cardio-renal patients with gastric or duodenal ulcer history. Nor should it be used in conjunction with mood-modifying drugs such as antidepressants or in psychiatric patients in general.


Renal diseases, and patients sensitive to the drug. In view of the limited and inadequate information at hand, no precise tabulation can be offered of additional contraindications.

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